Biomanufacturing

Heart-On-A-Chip Achieves Faster Delivery Time

Columbia University researchers recently generated beating cardiac tissue from induced pluripotent stem cells, human cells that are able to differentiate into nearly any cell type. Using physical conditioning, the researchers produced samples with the hallmarks of mature heart tissue with just four weeks of cell culture. The work paves a concrete pathway to functional heart-on-a-chip platforms.

Menaka Wilhelm
May 21, 2018
Injectable Bandage Stops Internal Bleeding of Severe Wounds

Biomedical engineers at Texas A&M University developed a hydrogel made from nanoflakes of synthetic clay and sugar chains extracted from seaweed. The gel could act as an injectable bandage to stop internal bleeding on a battlefield, in a surgical suite, or at an accident site.

Melissae Fellet
May 14, 2018
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Push to Scale Up Cell Therapy Manufacturing

Cellular Biomedicine Group, a clinical-stage biopharmaceutical company that develops immunotherapies for cancer and stem cell therapies for degenerative diseases, recently partnered with GE Healthcare to build a platform to produce therapies at scale for clinical trials. Aims to solve challenge of developing enough genetically modified cells to test products on large populations.

Menaka Wilhelm
April 30, 2018
Bioprinting Better Artificial Joints

Lorenzo Moroni and his team at University of Maastricht's Institute for Technology-Inspired Regenerative Medicine (MERLN) in The Netherlands, use 3D bioprinting to create "smart scaffolds," which they seed with patient stem cells and growth factors to produce structures that behave like natural cartilage tissues.

Melissa Lutz Blouin
April 30, 2018
Bacteria Opens Vents to Release Sweat from Athletic Shirt

Bioengineer, entrepreneur, MIT grad, designer Wen Wang invented an athletic-wear fabric that uses bacteria-activated vents to cool down the wearer.

Mark Crawford
April 23, 2018
Engineering Safety in Cell Therapy

Joseph Wu Director of the Stanford Cardiovascular Institute and Professor of Medicine and Radiology at Stanford University, discusses the rise of engineered cell and tissue products for use in patients. While these products are now technically advanced and better suited for the clinic, there continues to be issues around patient safety that need to be monitored and mitigated for routine use and mass production.

Tanuja Koppal
April 23, 2018
New Drug Program Takes DNA Damage Response Treatment to Next Step

A new nuclease inhibitor drug program could lead to the commercialization of novel DNA damage response (DDR) treatments for female breast, ovarian, and other types of cancers.

Jeff O'Heir
April 09, 2018
Mini Guts Could Improve Personalized Therapy Production

Researchers use minibioreactor arrays to study the gut, coupling them with high-throughput screening techniques to examine the effects of different therapies on digestive system diseases. Reported by AABME.org

Melissa Lutz Blouin
April 02, 2018
Breaking Down Virus Shells to Improve Therapy Deliveries

Rice University researchers have found that breaking down a virus’s tough outer shell creates nanoparticles that could improve the delivery of chemotherapies and other medicines to diseased cells.

John Tibbetts
March 26, 2018
Putting Skin in the Game

This “skin on a chip” bioreactor can help researchers study and treat keloid disease and other forms of extreme scarring.

John Kosowatz
January 16, 2018
Industry Confronts Challenge of Shipping Cells for Therapy

A new system may help solve the problem of shipping cells between laboratories and hospitals and clinics by developing an alternative to cryopreservation.

Alan Brown
January 16, 2018
Virus Shortage for Cell Therapies Creates Engineering Opportunity

Engineering and manufacturing expertise could ease the shortage of viral vectors used for drug delivery in the booming gene therapy market.

Michael MacRae
January 08, 2018
Heat-Emitting Nanoparticles Could Save Donor Organs

A new technique using heat-emitting nanoparticles helps doctors reheat cryocooled donor organs rapidly enough to prevent ice recrystallization, which cracks and destroys organs.

Theresa Sullivan ...
January 02, 2018
Podcast: Augmented Biology Makes Ears from Apples

Professor Andrew Pelling of Pelling Lab discusses his work in augmented biology and growing human tissue on cellulose scaffolding made from apples and other fruits and vegetables.

Jeff O'Heir
January 02, 2018