Cell therapy manufacturing is a new discipline where production of adult and pluripotent stem cell types are required for cell therapies. Several hundreds of clinical trials with adult mesenchymal stem cells for therapies such as auto-immune diseases, bone, cartilage repair and stroke are looking promising. For the pluripotent stem cell therapies, retinal pigment epithelial cells, pancreatic islet progenitors and neurons are being applied for treating blindness, diabetes and Parkinson’s disease in early stage clinical trials.
The first viable prototype of an artificial lung offers new hope for the more than one thousand people awaiting lung transplants across the United States.
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Barcoded nanoparticles deliver nucleic acids to treat cancer, viral infections, and neurodegenerative diseases.
Researchers have improved the ability of cancer-killing T-cells to target pancreatic tumors rather than healthy tissue by engineering the cells to produce more receptors.
For the first time in medical history, a team of researchers has grown and sustained blood stem cells in a bioreactor. The resulting cells could replace painful bone marrow transplants used to produce hematopoietic cells in patients suffering from leukemia and other blood cancers.
Using an intermediate adaptor cell gives clinicians more control over dosage and reverses a potentially fatal side effect of CAR T-cell therapy.
Georgia Tech researchers have developed a way to remotely activate the modified T cells from outside the body using a near-infrared laser that very precisely targets cancerous tumors.
Scientists at Harvard’s Wyss Institute for Biologically Inspired Engineering have transformed CRISPR into a powerful mutation surveillance and disease prevention tool.
After a decade of work in his lab at the Howard Hughes Medical Institute, Eric Betzig has developed a microscope that presents an unprecedented picture of subcellular activity in 3D living color.
A new device captures circulating tumor cells (CTCs) in the blood stream, providing a new avenue for early detection of metastatic cancer, as well as opportunities to test the source of the cells or the effectiveness of ongoing treatment.
Columbia University researchers recently generated beating cardiac tissue from induced pluripotent stem cells, human cells that are able to differentiate into nearly any cell type. Using physical conditioning, the researchers produced samples with the hallmarks of mature heart tissue with just four weeks of cell culture. The work paves a concrete pathway to functional heart-on-a-chip platforms.
Columbia University engineers use a soft mesh scaffold to produce a dramatically higher amount of functional T cells from blood taken from leukemia patients.
Harvard professor George Church discusses advances in portable genome monitoring as well as recent developments in the anti-aging therapies for which is he is so well known.
Lorenzo Moroni and his team at University of Maastricht's Institute for Technology-Inspired Regenerative Medicine (MERLN) in The Netherlands, use 3D bioprinting to create "smart scaffolds," which they seed with patient stem cells and growth factors to produce structures that behave like natural cartilage tissues.