Cell Therapy

Heart-On-A-Chip Achieves Faster Delivery Time

Columbia University researchers recently generated beating cardiac tissue from induced pluripotent stem cells, human cells that are able to differentiate into nearly any cell type. Using physical conditioning, the researchers produced samples with the hallmarks of mature heart tissue with just four weeks of cell culture. The work paves a concrete pathway to functional heart-on-a-chip platforms.

Menaka Wilhelm
May 21, 2018
Simple Solution Supercharges T-Cell Production

Columbia University engineers use a soft mesh scaffold to produce a dramatically higher amount of functional T cells from blood taken from leukemia patients.

Cassie Kelly
May 14, 2018
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Podcast: George Church on Portable Genome Monitoring, Aging, and More

Harvard professor George Church discusses advances in portable genome monitoring as well as recent developments in the anti-aging therapies for which is he is so well known.

May 07, 2018
Push to Scale Up Cell Therapy Manufacturing

Cellular Biomedicine Group, a clinical-stage biopharmaceutical company that develops immunotherapies for cancer and stem cell therapies for degenerative diseases, recently partnered with GE Healthcare to build a platform to produce therapies at scale for clinical trials. Aims to solve challenge of developing enough genetically modified cells to test products on large populations.

Menaka Wilhelm
April 30, 2018
Bioprinting Better Artificial Joints

Lorenzo Moroni and his team at University of Maastricht's Institute for Technology-Inspired Regenerative Medicine (MERLN) in The Netherlands, use 3D bioprinting to create "smart scaffolds," which they seed with patient stem cells and growth factors to produce structures that behave like natural cartilage tissues.

Melissa Lutz Blouin
April 30, 2018
Engineering Safety in Cell Therapy

Joseph Wu Director of the Stanford Cardiovascular Institute and Professor of Medicine and Radiology at Stanford University, discusses the rise of engineered cell and tissue products for use in patients. While these products are now technically advanced and better suited for the clinic, there continues to be issues around patient safety that need to be monitored and mitigated for routine use and mass production.

Tanuja Koppal
April 23, 2018
CRISPR Breakthrough Fuels Hope and Fear

For the first time, the revolutionary gene-editing technology called CRISPR-Cas9 was used to repair a disease-causing genetic flaw in viable human embryos and prevent the mutation from being passed to future generations.

Michael MacRae
April 16, 2018
New Drug Program Takes DNA Damage Response Treatment to Next Step

A new nuclease inhibitor drug program could lead to the commercialization of novel DNA damage response (DDR) treatments for female breast, ovarian, and other types of cancers.

Jeff O'Heir
April 09, 2018
Breaking Down Virus Shells to Improve Therapy Deliveries

Rice University researchers have found that breaking down a virus’s tough outer shell creates nanoparticles that could improve the delivery of chemotherapies and other medicines to diseased cells.

John Tibbetts
March 26, 2018
The Challenges and Promise of Cell Therapy Production

Dr. Patrick Hanley, assistant research professor of pediatrics in the Center for Cancer and Immunology research at the Children’s Research Institute in Washington D.C. and director of the Good Manufacturing Practices cell therapy laboratory at Children’s National Health System, on the new developments in the design and manufacturing for T cell therapies. He discussed ways in which technology can help simplify the methodologies and bring consistency and scalability to cell manufacturing.

Tanuja Koppal
March 12, 2018
Engineering Consortium Focuses on Cell Therapy Production

Georgia Tech Engineers created an organization to develop standards and production processes designed to mass produce life-saving cell-based therapeutics at affordable prices. Via AABME.

Nancy S. Giges
March 05, 2018
Doctors Reach for Remote Control to Improve Cancer Care

A new ultrasound technique that manipulates immune cells from outside the body could be the future of cancer care.

Tim Sprinkle
March 05, 2018
Molecular Mailman Improves Delivery of Gene Therapy

Researchers discover new molecular linker that orients targeting antibodies to help nucleic-acid filled particles reach target cells via AABME

Melissae Fellet
February 26, 2018
Scaffold-Grown Tumor Cells to Personalize Cancer Treatments

Testing drugs against patients’ cancer cells—without subjecting patients to chemotherapy—could lead to better, faster treatment.

Menaka Wilhelm
February 12, 2018